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간행물 검색
Clinical benefits of coronary CT angiography in preventing cardiovascular complications among renal transplant recipients
Si Youn Kim, Sangmi Lee, Sojung Yoon, Su Hyung Lee, Shinchan Kang, Geun Woo Ryu, Seonyeong Lee, Hyung Woo Kim, Kyu Ha Huh, Beom Seok Kim
2020 ; 2020(1):
    Coronary CT | cardiovascular | Kidney transplantation | graft function
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춘계학술대회 초록집
The aim of this study is to investigate whether performing coronary CT angiography in KT recipients is beneficial in preventing cardiovascular complications in long term. Respective analysis was performed on 281 patients who underwent renal transplant between March 2011 and May 2014 at Severance Hospital. Only patients with no history of coronary artery disease and with no signs or symptoms suggestive of cardiovascular disease during the past month were enrolled in the study. Study population was categorized into intervention group that underwent coronary CT (n=86) and the control group that didn’t go through coronary CT (n=195). The severity of CAD according to coronary CT was also divided into mild CAD, 1 vessel obstructive, 2 vessels obstructive (or in the proximal left anterior descending), and 3 vessels obstructive (or left main). During a mean follow up duration of 6.5 years, the incidence rate of MACE in total patients was 7.68 (95% CI: 4.55 - 13.0) events per 1000 person-year. And the incidence rate of MACE was much lower in the intervention group who had proper management after coronary CT surveillance: 3.46 (95% CI: 0.87 – 13.8) and 9.63 (95% CI: 5.47 - 17.0) events per 1000 person-year in intervention and control group, respectively. Through multivariate Cox proportional hazard model adjusted with confounding factors, surveillance through coronary CT was determined as an independent factor that reduces the risk of cardiovascular complications in renal recipients (HR=0.07 [95% CI: 0.01 - 0.49], P=0.007). The mean 3-year eGFR were 73.5 ± 19.7 and 77.2 ± 15.9 mL/min/ 1.73 m2 in intervention and control group, respectively, and there was no significant difference between two groups (P=0.131). High detection rate of CAD through coronary CT and with proper management combined, it leads to much lower incidence rate of MACE compared with the control group in long term.
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