Kidney failure causes many death and disability through ought world and for the treatment of kidney disorders scientist have limited medication including some herbal based preparation also have some limitation. Flavonoids have an attractive candidate due to its health beneficial effect and safety issue. Hyperin, an important flavonoid have cardioprotective, antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, antiparasitic, hepatoprotective and antispasmodic activity. Therapeutic importance and applicability of pure phytoconstituents for the treatment of kidney disorders have been developed in the present investigation through data mining by the help of numerous in-vitro and in-silico methods. Further importance of hyperin in various form of kidney disorders were also summarized in the present investigation. The structure-based computational approach combining molecular docking was applied to develop new effective medicine against kidney disorders through hyperin. An in-silico study was performed to confirm effectiveness of hyperin against enzymes responsible for the development of kidney disorders. Data study signified the importance of hyperin in rat basilar artery smooth muscle cells and some kidney disorders related to oedema. Further hyperin also modulate superoxide dismutase, glutathione peroxidase and LDH activities which could be used for the treatment of kidney disorders. Importance chemical and biochemical aspects of molecular docking underlying urinary pathophysiology was also developed and designed. Ability of hyperin to bind enzyme using docking study showed importance of hyperin against kidney disorders. Emerging roles of hyperin in the modern medical science for the treatment of kidney disorders through various in-silico molecular docking study was developed.