Worsening of chronic kidney disease (CKD) is influenced by inflammatory process, oxidative stress, and apoptosis. While, curcumin is well-known for its anti-inflammatory, anti-oxidant, anti-apoptosis effect. This study aims to determine the effect of curcumin in improving or preventing worsening of CKD.   A systematic literature was performed using Pubmed and BMJ. Curcumin and chronic kidney disease were used as the search term. A systematic review of published studies was performed with PRISMA statement. Studies which had randomized control trial with Animal Model as design study were included.    Four randomized control trials (RCTs) had been selected and identified from 139 studies. All RCTs showed that there are improvements in kidney function on curcumin effect. Overall, curcumin has several effects which lead to the decline in Cr, BUN and urine protein/cr/albumin, also the rise of CCr. Two RCTs showed a decrease in body weight of kidney, but the other two RCTs showed different results which were not significantly different and curcumin, on contrary, increased the body weight. The improvement of kidney function resulted from the benefit of curcumin as an anti-inflammatory, anti-oxidant, and anti-apoptosis agent. Curcumin was able to protect and improve kidney by inhibiting prostaglandin E2 production and nitric oxide, protecting from oxidative injury, increasing the level of reduced glutathione, declining TNF-α, and reducing lipid peroxidation.   Curcumin prevents worsening of CKD and might be improving renal function by its anti-inflammatory, anti-oxidant, anti-apoptosis effect. However,  further clinical trials with larger populations are needed to more accurately evaluate the effect of curcumin in renal function.