The aim of this review is to know the potential of therapeutic microRNA miR-21 and miR-29 for the treatment of renal fibrosis and  chronic kidney disease The method used four search engines that continued by 4 inclusions and 3 exclusion criteria to be analyzed. Our review was arranged by 60 Journals selected by this method. Several study about the role of MicroRNA  miR-21 and miR-29 as Regulators of Cellular function in fibrotic formation have been colected. Study showed that antifibrotic effects have been reported for all of the miR-21 and miR-29 family member. Streptozotocin-induced diabetic miR-21 and miR-29 transgenic mice showed 164 improved renal function with less glomerular fibrosis and inflammation, and better podocyte 165 viability compared to diabetic WT mice. miR-21 and miR-29  have important role in decreasing  fibrotic formation to prevent chronic kidney disease