Objective: This study is a cross-sectional study of a multi-center cohort that underwent kidney biopsy at 8 university hospitals affiliated with the College of Medicine Catholic University of Korea between January 2015 and May 2020 were diagnosed with IgAN.  A total of 480 patients were enrolled in final cohort. Patient were divided into 2 groups that according to following diagnostic criteria, group 1; <150mg/dL, group 2; ≥150mg/dL.   Methods: In Multivariable linear regression analysis showed that the that percent of GS, SS and CA, MME, MCP, ECP scores were positively associated with TG level after adjusting for clinical and laboratory parameters. The odd ratio and 95% CI for high score of GS, SS, MME, MCP and ECP between two TG groups.  Serum TG <150mg/dL group was considered as reference group in binary logistic regression. HyperTG group showed more higher risk for global sclerosis and segmental sclerosis, after adjusting for age, sex, systolic BP (Model 1) and with model 1 plus glucose, ALT, HDL-C, Total cholesterol, uric acid, UPCR (Model 2) and Model 2 plus eGFR, BMI (Model 3) Results: In linear multivariable analysis, the percentage of glomerular sclerosis and mesangial proliferation and capsular adhesion were positively associated with TG level. Multivariable logistic regression demonstrates that hyperTG is independently increase risk for glomerular sclerosis compared with normal TG group considering clinical variables. Conclusions: Objective: IgA nephropathy is most common glomerulonephritis disease in world wide. There are many clinical factors that affect IgAN prognosis or histopathology. However, there are only few studies that analysis focused on the histopathologic features between IgA nephropathy with hypertriglyceridemia and related lipid profiles. So, we evaluate histopathologic features in IgAN between HyperTG group compared to normal TG group.  Methods: This study is a cross-sectional study of a multi-center cohort that underwent kidney biopsy at 8 university hospitals affiliated with the College of Medicine Catholic University of Korea between January 2015 and May 2020 were diagnosed with IgAN.  A total of 480 patients were enrolled in final cohort. Patient were divided into 2 groups that according to following diagnostic criteria, group 1; <150mg/dL, group 2; ≥150mg/dL.   Results: In Multivariable linear regression analysis showed that the that percent of GS, SS and CA, MME, MCP, ECP scores were positively associated with TG level after adjusting for clinical and laboratory parameters. The odd ratio and 95% CI for high score of GS, SS, MME, MCP and ECP between two TG groups.  Serum TG <150mg/dL group was considered as reference group in binary logistic regression. HyperTG group showed more higher risk for global sclerosis and segmental sclerosis, after adjusting for age, sex, systolic BP (Model 1) and with model 1 plus glucose, ALT, HDL-C, Total cholesterol, uric acid, UPCR (Model 2) and Model 2 plus eGFR, BMI (Model 3) Conclusions: In linear multivariable analysis, the percentage of glomerular sclerosis and mesangial proliferation and capsular adhesion were positively associated with TG level. Multivariable logistic regression demonstrates that hyperTG is independently increase risk for glomerular sclerosis compared with normal TG group considering clinical variables.