Objective: In total, seventy patients with biopsy-proven lupus nephritis with a renal biopsy-confirmed diagnosis of LN class III through V and received induction therapy were selected from the Catholic Medical Center Glomerulonephritis Registry. The baseline clinical characteristics were obtained when a renal biopsy was performed. After induction therapy, we divided the patients into two groups, which are response group and non-response group. Responder group was defined as patients achieved complete remission or partial remission and non-responder group was defined as patients failed to achieve response. Methods: Forty-seven (67.1%) patients achieved complete remission or partial remission and twenty-three (32.9%) patients failed to achieve response. Low serum creatinine level, low estimated GFR and low UPCR was significantly associated with the response group (p=.002, p-value 0.009 and p=0.031, respectively). However, factors such as C3 (p=0.928), C4 (p-value 0.798), anti-dsDNA (p=0.173) showed no statistical significance between two groups. Results: Our data suggest that baseline serum creatinine, estimated GFR, and UPCR can predict treatment response after induction in patients with lupus nephritis. Conclusions: Objective: As one of the manifestations of SLE, Lupus nephritis can lead extensive kidney injury and renal function impairment. Despite of the standard immunosuppressive therapy for Lupus nephritis, some patients can not achieve remission state. In this study, we investigated the clinical predictors for treatment response in Lupus nephritis. Methods: In total, seventy patients with biopsy-proven lupus nephritis with a renal biopsy-confirmed diagnosis of LN class III through V and received induction therapy were selected from the Catholic Medical Center Glomerulonephritis Registry. The baseline clinical characteristics were obtained when a renal biopsy was performed. After induction therapy, we divided the patients into two groups, which are response group and non-response group. Responder group was defined as patients achieved complete remission or partial remission and non-responder group was defined as patients failed to achieve response. Results: Forty-seven (67.1%) patients achieved complete remission or partial remission and twenty-three (32.9%) patients failed to achieve response. Low serum creatinine level, low estimated GFR and low UPCR was significantly associated with the response group (p=.002, p-value 0.009 and p=0.031, respectively). However, factors such as C3 (p=0.928), C4 (p-value 0.798), anti-dsDNA (p=0.173) showed no statistical significance between two groups. Conclusions: Our data suggest that baseline serum creatinine, estimated GFR, and UPCR can predict treatment response after induction in patients with lupus nephritis.