Objective: In our study, we collected data from 60 patients undergoing hemodialysis treatment at the Medvic Dialysis Center and performed statistical analysis on Stata-17 and excel programs. Methods: Serum β-2 microglobulin in a total of 60 patients was averaging 23.5 mg/l, and the mean Glomerular filtration rate (GFR) was 9 ml/min/1.73 m2. There were no statistically significant differences in β-2 microglobulin levels depending on the patient's age, but β-2 microglobulin levels tended to increase with the age of the patient (p = 0.415). The mean level of β-2 microglobulin was 26.7 mg/l in over 60 years of age, 25.2 mg/l in 41-50 years of age, and 21.3 mg/l in 51-60 years of age. There were no statistical differences in the study of β-2 microglobulin levels depending on the year of hemodialysis treatment (p = 0.257). The average level of β-2 microglobulin in patients with GFR≥5 ml/min/1.73 m2  was 14.44 mg/l and inpatient with GFR<5 ml/min/1.73 m2 was 28.09 mg/l. According to decreasing of GFR  the average level of β-2 microglobulin was tended to increase relatively (p=0.422). Total of the 60 patients, 11 had clinical signs, 2 hands x-rays showed a narrowing of the distance between the Distal Inter Phalangeal, Proximal Inter Phalangeal in 15 patients, multiple sclerosis in 20 patients, and osteoarthritis in 8 patients. Results: Our study, the first time determined serum β2 microglobulin in patients who maintain hemodialysis for 4 years or more in Mongolia, the mean serum β2 microglobulin level was 23.5 mg/l and clinical symptoms were found in 20% of patients in the study. Conclusions: Objective: To determine for the first time in Mongolia the level of β-2 microglobulin in the plasma of patients who have undergone hemodialysis treatment for 4 years or more and to study it in relation to clinical symptoms. Methods: In our study, we collected data from 60 patients undergoing hemodialysis treatment at the Medvic Dialysis Center and performed statistical analysis on Stata-17 and excel programs. Results: Serum β-2 microglobulin in a total of 60 patients was averaging 23.5 mg/l, and the mean Glomerular filtration rate (GFR) was 9 ml/min/1.73 m2. There were no statistically significant differences in β-2 microglobulin levels depending on the patient's age, but β-2 microglobulin levels tended to increase with the age of the patient (p = 0.415). The mean level of β-2 microglobulin was 26.7 mg/l in over 60 years of age, 25.2 mg/l in 41-50 years of age, and 21.3 mg/l in 51-60 years of age. There were no statistical differences in the study of β-2 microglobulin levels depending on the year of hemodialysis treatment (p = 0.257). The average level of β-2 microglobulin in patients with GFR≥5 ml/min/1.73 m2  was 14.44 mg/l and inpatient with GFR<5 ml/min/1.73 m2 was 28.09 mg/l. According to decreasing of GFR  the average level of β-2 microglobulin was tended to increase relatively (p=0.422). Total of the 60 patients, 11 had clinical signs, 2 hands x-rays showed a narrowing of the distance between the Distal Inter Phalangeal, Proximal Inter Phalangeal in 15 patients, multiple sclerosis in 20 patients, and osteoarthritis in 8 patients. Conclusions: Our study, the first time determined serum β2 microglobulin in patients who maintain hemodialysis for 4 years or more in Mongolia, the mean serum β2 microglobulin level was 23.5 mg/l and clinical symptoms were found in 20% of patients in the study.