Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune complex deposits, inflammatory cell infiltrations in multiple organs, and approximately half of the patients affected kidney.  The histological class, degree of activity/chronicity affected the therapeutic plan and prognosis in lupus nephritis. Thus, we intend to elucidate the correlation between lymphangiogenesis and activity indices in LN patients. Methods: This study was reviewed and approved by the Institutional Review Board of Jeonbuk National University Hospital (CUH- 2020-07-032-001). We reviewed medical records for the biopsy-proven lupus nephritis and immunohistochemistry for D2-40 was performed. D2-40 positive lymphatic vessels were counted in the whole cortex of biopsy specimens, and the density of lymphatics was determined by computer-assisted morphometric analysis (magnification x200).  Results: Table 1 shows the clinical characteristics of the patient in our study. All six patients were women, demonstrating a female predominance in lupus, and renal manifestation occurred firstly in two patients at the time of diagnosis of lupus. In addition, four patients were proliferative lupus nephritis (e.g., ISN/RPS class III or IV) and showed high ANA titer, lower C3 levels, higher activity indices. Figure 2 describes the correlation between expression of D2-40 positive lymphatic vessels and lupus activity indices, and two factors have a positive correlation. (p value=0.0302) Conclusions: The higher the activity indices, the more the expression of lymphatic vessels in lupus nephritis, which may help set treatment target in the future.