Introduction: Pleuroperitoneum leak is a rare non-infectious complication of CAPD, but serious condition that causes inadequacy of CAPD. Its occurrence varies from days to years after starting CAPD. Treatment can be conservative or surgery. We report three cases of pleuroperitoneum leak in CAPD that improved with two alternative conservative therapy. Illustration: The first case is a 62-year-old woman ESRD with CAPD for 10 years, has right pleural effusion. Pleural fluid analysis revealed high glucose levels, no evidence of infection. Pleural puncture was performed to reduce tightness and then stop CAPD, transition to hemodialysis. After that the pleural effusion improves. Cases 2 and 3, women 45 and 31 years-oldboth had ESRD, received CAPD therapy. After CAPD started, both patients experienced shortness of breath, right pleural effusion was found. Analysis of the effusion fluid both showed high glucose levels, no evidence of infection. The second case, the CAPD therapy was temporarily discontinued (2 months) and transitioned to hemodialysis during this time. In the evaluation, pleural effusion improved, CAPD is restarted with small volumes, increasing gradually. In the third case because of refused to transition to hemodialysis, PD was maintained but reduced fluid volume, shortened dwell time, avoiding overnight dwells. Pleural puncture was continued throughout hospitalization with pleural fluid drainage daily. After treatment the pleural effusion improved. Discussion: Conservative therapy pleuroperitoneum leak in CAPD is usually temporary discontinuation of CAPD 2-6 weeks and temporary transfer to hemodialysis. However, the experience of recent case reports, continuous pleural fluid drainage combined with intermittent PD or automatic PD can be used as an alternative. Its associated with being able to restart CAPD earlier. Conclusion: These 3 case reports show that conservative teraphy with temporary transition to hemodialysis or continuous pleural effusion drainage is useful for pleuroperitoneum leak in CAPD.