Objectives:  Glycemic control is fundamental to optimize the care of hemodialysis patients (HD) with diabetes. While fasting blood glucose (FBG) control is the most important for ideal glycemic management, there is no clear target to minimize the mortality risk in HD population. The aim of the study is to suggest the ideal FBG target in the diabetic HD patients. Methods:  We reviewed the National Health Insurance Database of Korea, screening 161,855 patients who received maintenance HD treatment between 2002 and 2018. A total of 6,605 patients were included, who received national health screening examination and developed diabetes. The primary endpoint in this study was the association between time-updated FBG and all-cause mortality. Results:  During an average of 6.55 years of follow-up, the mean fasting glucose level was 123.84 mg/dL in the patients. Compared to patients with FBG 80-100 mg/dL, adjusted hazard ratio (HR) for all-cause mortality was significantly higher in patients with <80 mg/dL (HR, 1.17; 95% CI, 1.08-1.27). HR of mortality was also increased as FBG was increased [adjusted HR: 1.08 (95% CI, 1.02-1.27), 1.18 (95% CI, 1.10-1.28), 1.31 (95% CI, 1.20-1.43) and 1.30 (95% CI, 1.21-1.39) for patients with FBG 100-125, 125-150, 150-180 and ≥180 mg/dL, respectively]. Patients who had age of <65 years, female gender, normal body mass index or less comorbidity score were significantly associated with lower mortality risk at FBG <80 mg/dL, compared to those with FBG 85–100 mg/dL.  Conclusions:  Patients with 80≤FBG<100 mg/dL were significantly associated with lower risk of all-cause mortality than those with FBG <80 mg/dL or ≥ 100 mg/dL. In addition, patient-specific conditions allowed even tighter FBG target for lower risk of mortality.