Objectives: Hypertension is a major cardiovascular risk factor in hemodialysis patients. However, optimal target blood pressure in hemodialysis patient is not yet clear. The purpose of this study to find the adequate blood pressure range for optimal survival of Korean hemodialysis patients using Korean ESRD registry and pooled analysis. Methods: Korean ESRD registry dataset were obtained from Korean Society of Nephrology. Hemodialysis patients were classified according to their systolic blood pressure and diastolic blood pressure at intervals of 10 mmHg, respectively. With Cox regression analysis, the association between SBP or DBP groups and all-cause mortality risk were found. Subsequently, pooled analysis with previous studies about association between blood pressure and mortality from various country were conducted.  Results:   Of the 70780 hemodialysis patients, 13714 (19.4%) died in 2433 [1257.5-4078] days. Mean SBP and DBP were 143.0±19.6 and 78.6±12.0, respectively. In multivariable Cox regression, the patients wih SBP <100mmHg, 100-110mmHg, 180-190mmHg, 190-200mmHg and > 200 mmHg showed 1.20-, 1.17-, 1.19- 1.20-and 1.43-times of mortality risk compared to SBP 130-140mmHg, respectively. Meanwhile, various levels of DBP showed no significant difference in mortality risk. In subgroup analysis, U-shaped association between SBPs and mortality were only significant in young age<70. The patients with diabetes showed elevated risk of mortality only in >200mmHg, while the patients without diabetes showed elevated mortality in low SBP ranges. In pooled analysis with other previous studies stratified SBP as 20mmHg interval, the studies consistently showed elevated risk in SBP <120mmHg but the risks in high SBP ranges, 140-160mmHg and 160-180mmHg, were not consistent. Conclusions: Based on the U-shaped association between SBP and mortality, we propose SBP in the range of 110-180 mmHg as suitable target and 130-140 mmHg as optimal target in hemodialysis patients. And pooled analysis with present study provides consistent evidence that low SBP should be avoided in hemodialysis patients.