Objectives: Acute kidney injury (AKI) was common severe complication and one of causes of high mortality rate in intensive care units patients. Many severe AKI patients has received renal replacement therapy and the patients with hemodynamic instability receive the continuous renal replacement therapy (CRRT). Many studies was focused on scoring systems on CRRT patients outcomes. But Scoring systems were complicated. So, We used simple inflammation markers; Platelet to lymphocyte ratio(PLR) and neutrophil to lymphocyte ratio(NLR) to prognostic factors of AKI outcomes. Methods: We retrospectively studied on adult patients who diagnosis AKI and performed CRRT on our hospital from January 1, 2010 to December 31, 2016. We checked the laboratory findings when the inpatients with CRRT for severe non septic AKI.They were divided two groups by 28-day in hospital survival.The clinical manifestation associated with each groups were analyzed. The value was expressed by median (range).Results: January 1, 2010 through December 31, 2016 were initially screened .(n=920).We excluded patients who younger than 18years old and expired within 24hours of hospitalization Results:  January 1, 2010 through December 31, 2016 were initially screened .(n=920). We excluded patients who younger than 18years old and expired within 24hours of hospitalization. A total of 803 patients were included in the analyses. 510patients are death group and 293 patients are survive. The median age of patients were 70(20-91) year-old in death group and 65 (18-90) year-old in survival group. Death patients are lower Platelet lymphocyte ratio(PLR) than survival patients.[92.85(3.04-1190.36)vs. 129.77(5.91-1281.41),P=0.001. Death patients are lower neutrophil lymphocyte ratio(NLR) than survival patients.[11.08(2.01-161.83)vs. 12.42(5.91-326.67),P=0.009]. Univariate logistic regression analysis revealed PLR(177.00) was predictive factor for non septic AKI on CRRT 28-day mortality.[HR 1.467, 95% CI 1.084-1.986]. Other baseline characteristics and laboratory findings were no significantly different. Conclusions: PLR and NLR were a good predictive factors of inpatients with CRRT mortality.