Common complications at the Transplant Event and Immediate Post-transplant Period include surgical complications (such as lymphocele, urinary leak, bleeding, deep vein thrombosis, blood clot, etc…) and medical complications (such as infection, acute rejection, delayed graft function recovery, acute myocardial infarction, stroke, hyperglycemia (PTDM), and electrolyte imbalance. Early post-transplant infection could be donor-derived infection, recipient-derived infection, and nosocomial infections, most complications are minor and improve over time. Some complications are more serious and may require additional surgery or procedure. When the kidney transplant team wants to challenge difficult surgical subjects, such as decreased donor, recipients with diabetes mellitus, cardiovascular disease, or obesity, the challenge will be higher immediate post-transplant period. As the population ageing in Taiwan, more ESKD patients with cardiovascular disease, diabetes mellitus, and hypertension received kidney transplantation in the past decade. However, the lower selection criteria of donors and recipients will be associated with the higher risk of kidney transplantation. Deceased donor transplant recipients were at higher risk of death for a period of 180 days after the date of transplant surgery and then, had a lower risk of death. Thus, the kidney transplant teams in Taiwan have enrolled multidisciplinary experts to improve patients care, especially the management at the transplant event and immediate post-transplant period. The introduction of Point-of-Care Ultrasound (POCUS) helps serial examination of the graft kidney in the early post-operative period for early detection of the potential surgical complications. Many hospitals also establish the dashboard for inpatient blood sugar, acute kidney injury, and therapeutic drug level monitoring. Nephrologists play the critical role in the multidisciplinary responsibilities for renal transplantation to evaluate and management recipients and donors from the preoperative to perioperative periods and take care of their life-long chronic kidney disease management, be familiar with the adverse effects of immunosuppressive agents, and provide holistic health care for patients, living donors and their families.