Kidney recipients are at higher risk of developing skin cancer. The most common type is Squamous Cell Carcinoma (SCC) which is more aggressive and deadly. The aim of this case report is to inform the incidence of SCC in kidney transplant recipients at our hospital. Case illustration, an out patient 70 years old male routine control 8 years after kidney transplantation. Since 1 month ago, painless wound has appeared on the right forearm. After 2 weeks of treatment did not improve, the dermatologist suspected the possibility of cancer, referred him to the hospital for excision surgery. Anatomical pathology examination resulted in Squamous Cell Carcinoma, moderately differentiated. Family history of malignancy, the patient's father suffered from lung cancer. Body weight 71 kg, height 167 cm, BMI 25.46 kg/m2, vital signs within normal limits. Laboratory examination hemoglobin 13.4, creatinine 1.28, Tacrolimus 8.7. The patient received routine therapy with Adalat Oros 1x30mg, Candesartan 1x 16mg, Methyl Prednisolone 1x4mg, MMF 2x 180mg, Tacrolimus XL 1x2mg. Wide excision of the lesion was planned. The incidence of SCC is influenced by sunlight, genetics, male gender, smoking, immunosuppressant therapy, HPV infection. SCC in renal recipients is at higher risk for metastasis and mortality. If left untreated, the 3 years survival rate is only 56%. Preventife therapy include sunscreen with an SPF of at least 15, wearing hats and wide-brimmed clothing, and training in self-examination of skin and prevention of HPV transmission with protective contraception (condoms). Topical therapy to prevent regrowth. Metastases to lymph nodes and surrounding tissue require post-resection radiation. As a conclusion, renal recipient patients on long-term immunosuppressants are at risk of developing SCC. Prevention and management needed to improve morbidity and mortality.