Objectives: To explore whether the in-hospital mortality of patients with septic acute kidney injury ( SAKI ) can be improved after continuous renal replacement therapy ( CRRT ) with oXiris filter. Methods: A cohort study was conducted.302 SAKI patients treated with CRRT were divided into M150 group ( n1=174 ), oXiris group ( n2=61 ) and combined group ( n3=67 ). The laboratory indexes before and after CRRT and the in-hospital survival curves were compared. Results: After CRRT treatment, the IL-6 ( 397.00 [ 52.18,1555.50 ] VS 198.10 [ 39.23,597.20 ] mmol / L, P < 0.05 ), shock index ( 0.83 [ 0.70,1.02 ] VS 0.79 [ 0.61,0.99 ] , P < 0.05 )and APACHE II score( 21.26±7.28 VS 19.22±7.45, P > 0.05 ) of the combined group were lower than before. The mean arterial pressure ( MAP ) of the three groups was lower than before, but the decrease of MAP in the combined group was smaller than M150 group( − 0.78±20.04 VS − 6.68±22.63 mmHg, P > 0.05 ) and oXiris group( − 0.78±20.04 VS − 1.37±20.39 mmHg, P > 0.05 ). The patients were followed up until discharge after diagnosis of sepsis, the survival rate of the combined group was higher than oXiris group(X2=3.08, P > 0.05)and M150 group(X2=3.10, P>0.05). From admission to discharge, the survival rate of the combined group was higher than M150 group(X2=4.89,P＜0.05）. The in-hospital survival rates of oXiris group and M150 group were similar, P > 0.05. Conclusions: For SAKI patients treated with CRRT, there was no better short-term survival benefit when oXiris or M150 was used alone. However, compared with M150 monotherapy, the combination therapy had better in-hospital survival benefit, which may be achieved by improving hemodynamics, inflammatory response and organ function.