Objectives: Volatile organic compounds(VOCs) are group of organic chemicals that easily evaporate at room temperature considered one of the indicators of environmental pollution. VOCs have been reported to be associated with obesity and metabolic diseases in previous studies. We aimed to evaluate the association of VOCs and kidney function. Methods: We used the dataset from the Korea National Health and Nutrition Examination Survey (KNHANES) VIII (2019─2021). The urine creatinine-corrected VOCs concentration (BMA, 2MHA, 3,4MHA, PGA, MA, SPMA, 3HPMA, BPMA and DHBMA) was divided into tertile groups. CKD was defined as estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2. The association between urinary VOCs concentration and CKD was analyzed through multiple linear regression model. Results: A total of 1,319 participants was analyzed in this study. The urinary concentration of several VOCs (3,4MHA [3,4-Methylhexanoic Acid], PGA [Phenylglyoxylic Acid], MA [Maleic Acid], DHBMA [Dihydroxybenzene Mercapturic Acid]) have been found to have statistically significant association with reduced kidney function. ([3,4MHA] odds ratio(OR), 5.86; 95% confidence interval(95% CI), 1.30─26.45; p-value 0.023; [PGA] OR, 14.30; 95% CI, 1.53─133.78; p-value 0.014; [MA] OR, 5.38; 95% CI, 1.03─28.12; p-value 0.040; [DHBMA] OR, 4.14; 95% CI, 0.77─22.21; p-value 0.054). Conclusions: We found that urinary VOCs concentration showed the association with declined kidney function which could be used to be a predictive marker of CKD.