Objectives: Discussing the operational procedure, safety, and feasibility of replacing the Luer-type connector of a tunneled hemodialysis catheter after damage, aiming to prolong the catheter's lifespan, alleviate patient discomfort, and improve quality of life. Methods: The patient was a 41-year-old male with chronic renal failure, a history of diabetes, and hypertension. He had a right-sided tunnel-type blood dialysis catheter in place for maintenance hemodialysis for 80 months. On October 7, 2022, during dialysis, air leakage was found at the arterial end of the catheter. Examination revealed a 1.5 cm long crack at the arterial end Leur interface of the catheter. The catheter had been functioning well.After comprehensive evaluation and discussion among medical staff and the patient, it was decided to perform a Leur interface replacement using the peritoneal dialysis external short tube replacement method. Results: The Leur interface replacement procedure went smoothly, taking approximately 25 minutes. The patient experienced no discomfort, and after replacement, the catheter had no air leakage, bleeding, infection, or other complications. The catheter functioned well during dialysis, with no changes in blood flow rate, pump pressure, or venous pressure compared to before the replacement. The patient was highly satisfied. Conclusions: The Leur interface is a connection interface between the hemodialysis catheter and the extracorporeal circulation tube. With the prolonged placement time of the catheter and the repeated action of disinfectants, the interface can age and deteriorate, leading to cracks and damage. Once the Leur interface is damaged, air leakage and bleeding can occur during dialysis, significantly affecting treatment effectiveness and increasing the risk of infection. The method of repairing by replacing the catheter Leur interface is non-invasive, simple, safe, and effective. It does not require additional examinations, significantly shortens the patient's recovery period, and is beneficial for protecting the patient's limited vascular resources. It is worthy of clinical promotion.