Hypertensive kidney disease (HKD) is a major contributor to chronic kidney disease (CKD) and end-stage renal disease (ESRD), increasing cardiovascular risks. While RAAS inhibitors and diuretics are standard treatments, novel interventional nephrology techniques-renal denervation, baroreceptor activation therapy, and endovascular interventions-offer alternative strategies for blood pressure control and renal protection. This meta-analysis evaluates their effectiveness and safety. A systematic search was conducted in PubMed, ScienceDirect, Journal of Hypertension, Cochrane Library, Europe PMC, and Google Scholar using MeSH terms related to “Hypertensive Kidney Disease” and “Interventional Nephrology.” Studies published in the last 10 years were included if they assessed these interventions' efficacy in blood pressure control and renal function. Eligible study designs included RCTs, cohort studies, and case-control studies. A random-effects model estimated pooled effects, with heterogeneity assessed using I² statistics. Publication bias was evaluated via Egger’s test and Kendall’s Tau, while study quality was assessed using the Newcastle-Ottawa Scale. Statistical analyses were performed using R (MAJOR package) and RevMan. Seventeen studies met inclusion criteria. Egger’s test (1.838, p = 0.066) showed no significant small-study effects, and Kendall’s Tau (0.947, p < .001) indicated strong rank correlation. The Rosenthal fail-safe N (1905, p < .001) confirmed result stability. The pooled effect estimate was 1.43 (95% CI: 1.27–1.59), with I² = 0%, indicating minimal heterogeneity. The forest plot showed consistent favorability toward interventional approaches. Emerging interventional nephrology techniques offer a promising frontier in HKD management, demonstrating notable efficacy with minimal variability across studies. These innovations could enhance standard treatments by providing targeted blood pressure control and renal protection. However, large-scale RCTs are essential to validate their long-term benefits and establish clinical guidelines for widespread adoption.