iRenal angiomyolipoma(AML) is a benign hamartomatous neoplasm arising sporadically in 80% of cases and 20% resulting from secondary causes. Majority of renal AML ranging less than 4cm are asymptomatic, but AML exceeding 4cm may rupture and lead to flank pain and/or haematuria, but rarely do patients present with fever and/or dysuria. We report a case of a 48 year-old lady with no past medical history presenting with dysuria and fever 39°C. Rest of her vitals were stable. Physical examination revealed a soft abdomen but with positive right renal punch. Urine microscopy showed pyuria with microscopic haematuria, and urine culture showed mixed bacterial growth. Ultrasound showed a 4.6cm×5.2cm×4.7cm echogenic mass with internal vascularity in the right kidney upper pole. Computer tomography showed hypervascular soft soft tissue and macroscopic fat in the lesion. There were no signs of rupture or haemorrhage on scans. Her symptoms resolved after a course of cephalosporin, and she was given outpatient specialist follow-up. A PubMed search using keywords “renal angiomyolipoma”, “infection”, “cystitis”, “pyelonephritis” was performed to review relevant articles from start of time to present. Swapnil N et al. reported a case of superimposed pyelonephritis and cystitis in a patient with renal AML. Monge Mirallas JM et al. reported a case of a female with known renal AML presenting with fever, chills, and positive ipsilateral renal punch; histology of excised lesion showed granulomatous changes suggestive of chronic inflammation. M. Bide et al. reported a case of AML presenting as isolated high-grade fever which resolved after excision of lesion, suggesting a correlation. There is limited literature discussing the correlation of renal AML with infection; nevertheless we propose that our patient’s symptoms might be related to her underlying renal AML, based on existing literature this could be due to superimposed infection or release of inflammatory cytokines from the lesion.