Nutrition has become a critical factor in the mortality and morbidity of chronic kidney disease (CKD) patients. While dietary education is provided in clinical settings, it is often difficult for patients to consistently follow CKD-specific diets. CKD-specific meal plans categorized as medical food could potentially be a useful nutritional intervention, but well-designed studies are lacking. Therefore, we tried to evaluate the effectiveness of delivered CKD-specific meals compared to traditional dietary education for CKD patients. This prospective, randomized trial included 52 CKD patients. Of the participants, 26 received traditional education on a CKD diet, while the other 26 were provided with a CKD-specific meal plan. After 56 days of nutritional intervention, vital signs, blood and urine tests including kidney function, and nutrition indicators such as Body Mass Index, Patient-Generated Subjective Global Assessment (PG-SGA), and Mid-Arm Muscle Circumference (MAMC) were compared between the two groups. Out of 52 participants, 45 completed the study, and baseline characteristics are described in Table 1. After 56 days, the CKD-specific meal plan group showed statistically significant improvements in PS-SGA and MAMC compared to the education-only group. Blood pressure showed a decreasing trend in the CKD-specific meal plan group, with only systolic blood pressure exhibiting a statistically significant difference (-10 mmHg vs. +1 mmHg). No significant differences were observed between the two groups in kidney function markers, including creatinine, and spot urine protein/creatinine ratio. In the CKD-specific meal plan group, total cholesterol and LDL-cholesterol showed a decreasing trend compared to the education group. However, triglycerides significantly increased, and HDL-cholesterol decreased, both showing statistically significant differences (Table 2). This study demonstrated that CKD-specific meals led to significant improvements in nutritional indicators and blood pressure compared to dietary education. Based on this potential, further long-term studies are needed to assess their impact on improving kidney function.