The improved survival rates of patients with thalassemia have led to the identification of new complications, including renal diseases. In cases of end-stage kidney disease, kidney transplantation is regarded as the preferred treatment. However, research on kidney transplantation in thalassemia patients remains limited. We present the case of a transfusion-dependent alpha-thalassemia patient who underwent kidney transplantation due to end-stage kidney disease and maintained stable graft function over a six-year follow-up period. Notably, six years post-transplant, the patient demonstrated a creatinine level of 110 µmol/L and a glomerular filtration rate of 78 mL/min/1.73 m². Despite requiring blood transfusions every three months, the patient’s renal function remained stable throughout the follow-up period. This case highlights the viability and effectiveness of kidney transplantation as a long-term treatment option for patients with alpha-thalassemia and end-stage kidney disease, as well as the need for further research to better understand the long-term outcomes and challenges in this population.