ABSTRACT Background: Lymphocele is a common surgical complication in post-kidney transplantation with an incidence rate of 0.6% to 61%. Symptomatic lymphoceles, however, have a lower incidence rate at 0.03% to 26%, averaging 5.2%. Most lymphoceles are small, asymptomatic, and resolve on their own, but large lymphoceles (>6 cm) have an increased morbidity and often require urgent intervention. Case Report: A 44-year-old female with diabetic kidney disease who successfully underwent kidney transplantation at the right iliac fossa was readmitted due to right lower quadrant abdominal pain, decreased urine output and increased serum creatinine. Renal graft ultrasound revealed a perigraft fluid collection of 745 mL (15.4 x 16 x 5.8 cm), which was treated with ultrasound-guided percutaneous drainage. The procedure relieved her symptoms and improved her urine output. After follow-up care, her condition stabilized, and the lymphocele size was significantly decreased. Conclusion: Lymphoceles are a common post-kidney transplantation complication that usually resolves spontaneously. However, symptomatic lymphoceles require prompt diagnosis and intervention to prevent morbidity. Various treatment options, including percutaneous drainage and sclerotherapy, can effectively manage lymphoceles and improve patient outcomes, but recurrence remains a challenge, impacting patient well-being and healthcare resources.