Sleep disturbances and poor sleep quality are common in hemodialysis patients, affecting quality of life and increasing cardiac risks. This study aimed to identify risk factors using validated screening tools to guide early detection, recommend objective diagnostics for identified high risk patients to evetually provide comprehensive care, and ultimately improve health outcomes and reduce associated risks. A cross-sectional study was conducted involving 51 hemodialysis patients. Data on demographics, dialysis adequacy (Kt/V), body mass index (BMI), and sleep outcomes were collected. Validated tools, including the Berlin Questionnaire, Insomnia Severity Index (ISI), and Pittsburgh Sleep Quality Index (PSQI), were used to assess sleep disturbances. Statistical analyses were performed to identify significant associations The prevalence of SDB, moderate insomnia, and poor sleep quality was 68.6%, 31.4%, and 72.5%, respectively. Male sex was significantly associated with SDB (77.1% vs. 25%, p = 0.0005), moderate insomnia (81.3% vs. 51.4%), and poor sleep quality (73% vs. 28.6%). Inadequate dialysis adequacy (Kt/V <1.2) was strongly associated with SDB (54.1% vs. 0%), moderate insomnia (75% vs. 22.9%), and poor sleep quality. Overweight and obese patients were also more likely to have SDB (31.4% and 11.4%) and moderate insomnia (50%). Male sex, poor dialysis adequacy, and elevated BMI are significant risk factors for sleep disturbances in hemodialysis patients. Routine screening using validated questionnaires (Berlin, ISI, PSQI) offers a cost-effective strategy to identify high-risk individuals in resource-limited settings like the Philippines. Early detection allows nephrologists to implement timely interventions that improve dialysis adequacy, address weight management, and reduce complications such as cardiac comorbidities. For high-risk patients, recommending more objective assessments like polysomnography ensures comprehensive care and supports better long-term health outcomes and quality of life.