- Analysis of Clinical Outcomes According to Early Graft Dysfunction in Deceased Kidney Transplantation: Multicenter Cohort Study
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Suyeon Hong
2025 ; 2025(1):
Immediate graft function, Slow graft function, Delayed graft function, Deceased donor kidney transplant
- 논문분류 :
- 춘계학술대회 초록집
Slow graft function (SGF) is defined as failure of attainment of an absolute level of Cr by a given postoperative day (POD), Cr ≥2.5 on POD7 or Cr reduction ratio of <30% between POD1 and POD2. Delayed graft function (DGF) is defined as the need for dialysis during the first week after transplantation. Our study aims to evaluate the clinical long-term outcomes of SGF and DGF compared with immediate graft function (IGF). This was a Retrospective cohort analysis, time period between October 1996 to August 2022 with minimum follow up –1 year. Total DDKT done in this time period was 846. They were divided into 3 groups – IGF, SGF and DGF. Out of total renal transplants 65.6% (555) patients had IGF, 13.24% (112) patients had DGF and 21.16% (179) patients had SGF. Death censored graft survival at end of 5 year was 93.5% in IGF, 89.1% in SGF (p= 0.036) and 84.3% in DGF (p=0.003). Cumulative patient survival at end of 5 year was 95.1% in IGF, 94.6% in SGF (p=0.939), and 89.7% in DGF group(p=0.034). Acute rejection episodes were more prevalent in DGF group (31.4%), p=0.024, than SGF (20.2%) and IGF group (14.3%). SGF and DGF was associated with comparable increases in risk of graft failure compared to IGF (hazard ratio (HR) 1.56, 95% confidence intervals (CI) 1.02-2.18 for SGF and HR 2.20, CI 1.27-3.81 for DGF); For mortality, outcomes for SGF were similarly to IGF, both SGF and IGF were associated with lower risk relative to DGF (HR 0.58, CI 0.40-0.96 for SGF). In conclusion, SGF may be a marker for graft failure but not for mortality. SGF appear to represent an intermediate phenotype differ from IGF and DGF.