Non-traumatic spontaneous renal rupture on continuous ambulatory peritoneal dialysis (CAPD) is a very rare event, In most case, it is associated with acquired cystic kidney disease or the presence of renal cell carcinoma. Also, dialysis patients have a tendency to bleed because of platelet dysfunction. A 27-years old nulliparous woman presented with 2-3 month history of hypermonorrhea and 10 years history of CAPD by end-stage renal disease due to chronic glomerulonephritis. She was admitted to hospital due to an episode of hypermenorrhea accompanied pained by severe left flank pain without any traumatic event. Abdomenal CT scan shows that a large amount of hematoma of left kidney and retroperitoneal space. Renal arteriographic findings show no active bleeding focus. After 7days, follow-up CT scans shows bilateral hemothorax and laboratory findings was disseminated intravascular coagulation (DIC) features. Heparin free daily hemodialysis, conjugate estrogen, desmopressin, packed red blood and cryoprecipitate transfusion were performed. She was recovered and re-started the CAPD. In present report, we describe a case of DIC caused by hypermenorrhea after spontaneous renal rupture in a CAPD patient with acquired cystic kidney disease.