Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare disorder caused by exposure to certain medications that may cause a rash, fever, lymphadenopathy and hematologic abnormalities such as eosinophilia, thrombocytopenia and atypical lymphocytosis. 61-year-old woman with ongoing hemodialysis was presented with painful left wrist swelling and diagnosed to cellulitis. We first use ampicillin/sulbactam for 3days but there was no improvement. So, we changed antibiotics to vancomycin and the lesion of cellulitis was improved. During using of vancomycin, she developed a painful lymphadenopathy on left neck, whole body skin rash and fever. Neck computerized tomography scan shows an enhanced and variable sized lymphadenopathy in both carotid space and both lower lateral neck. Laboratory findings were eosinophil 17.7%, eosinophil count 3830/mm3, and AST/ALT 66/80 U/L. We performed lymph node fine needle aspiration and the result was polymorphic lymphocytic cells. We stopped vancomycin and used methyl prednisolone (PDS) for 1 mg/kg for 14 days and symptoms such as skin rash, lymphadenopathy and eosinophilia were improved. She discharged hospital after tapering PDS for 0.5 mg/kg. We describe here a case of DRESS syndrome after use of vancomycin in hemodialysis patient.