The aim of this study was to assess the association between different nutritional markers and bioelectrical impedance analysis (BIA)-derived phase angle (PhA) in patients with end-stage renal disease (ESRD) and to evaluate the predictive value of the PhA for malnutrition risk in these patients. We performed a cross-sectional study with 126 adult ESRD patients undergoing hemodialysis (HD) for ≥6 months, 44% females, 56% diabetics, with mean age of 62.02±13.1 years and the mean HD duration of 45.6±36.2 months. Based on the geriatric nutritional risk index (GNRI), the patients were categorized into either malnourished (GNRI ≤98) (Group 1, n=54) or normal groups (GNRI >98) (Group 2, n=72). We measured complete blood count, biochemical parameters, dialysis adequacy, BIA, and relative hand grip strength (HGS) in both groups.   Group 1 exhibited significantly higher average age (p<0.001) and lower PhA (p<0.001). All of the following parameters were lower in Group 1: serum creatinine (p<0.001), cholesterol (p=0.005), total lymphocyte count (TLC) (p=0.007), albumin (p<0.001), prealbumin (p<0.001), transferrin (p<0.001), and insulin-like growth factor-1 (IGF-1) (p=0.001). Although extracellular water/total body water (ECW/TBW) ratio (p<0.001) was higher in Group 1, body fat mass (p<0.001), body mass index (p<0.001), normalized protein nitrogen appearance (nPNA) (p=0.041), and relative HGS (p=0.044) were higher in Group 2. The PhA was positively correlated with TLC (r=0.381, p<0.001), creatinine (r=0.626, p<0.001), albumin (r=0.459, p<0.001), prealbimin (r=0.714, p<0.001), transferrin (r=0.413, p<0.001), IGF-1 (r=0.542, p<0.001), nPNA (r=0.356, p<0.001), and GNRI (r=0.550, p<0.001). On multiple regression analysis, prealbumin (p=0.003) and ECW/TBW ratio (p<0.001) were significant independent factors associated with PhA. Receiver operator characteristics (ROC) curve analysis suggested that proper PhA cut-off point for malnutrition risk was 4.2° with 71.8% sensitivity, 63.6% specificity.   The results of this study suggest that BIA-derived PhA can be considered as a useful marker of nutritional status in maintenance hemodialysis patients.