Persons with hypertension had multiplex and share common CVD risk factors as increasing risk for CKD. The affected of CVD risk factors with CKD stage 3 to 5 but not stage 2 was well established. Therefore, we examined the association of CVD risk score with CKD-2 in hypertensions. Among 2,150 hypertensions from 15 primary care units in Southern Thailand, 1,540 cases were eligible (CKD stage 1 or 2 = 1,404). CVD risk score was calculated based on the Framingham Heart Study-General Cardiovascular Risk Profile. Six traditional risk factors are systolic blood pressure, age, total cholesterol, HDL-C, diabetes, and smoking. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI equation in ml/min/1.73m2. GFR ≥90 indicated CKD-1, and GFR 60-89 with proteinuria indicated CKD-2.  There were 4.6%, 50.1%, and 45.3% of hypertensions with low-, moderate-, and high-risk. Prevalence of CKD-2 was 60.5%. A high-risk group had highest prevalence of CKD-2 as compared with the moderate-, and low-risk groups (72.6% vs. 53.4% vs. 18.8%, p<0.0001). Increment risk for CKD-2 was associated with per 1 unit increased in score on CVD risk profile. Unadjusted OR was 1.19 (Wald 124.95 [95%CI 1.15-1.23], p<0.0001). Adjusted ORs in each model are as followed: model 1, by sex (Wald 112.91 [OR 1.19, 95%CI 1.15-1.22], p<0.0001); model 2, by added social determinant factors (Wald 54.38 [OR 1.13, 95%CI 1.09-1.17], p <0.0001); model 3, by added triglyceride, LDL-C, waist circumference and body mass index (Wald 43.32 [OR 1.13, 95%CI 1.09-1.17], p<0.0001); and the full model, by added hypertension medications (Wald 40.92 [OR 1.13, 95%CI 1.08-1.17], p<0.0001). CVD risk score was a strongly and independently associated with CKD stage 2. A comprehensive risk assessment on CVD risk profile may usefully to early detected those patients who are at highly risk for developing CKD.