This study aims to investigate the role of religion in individual decisions to donate body organ including the kidney.   This study used a juridical normative method that was analytical description of law sociology and normative qualitative analysis of secondary data by examining the agreements of islamic organizations (Muhammadiyah and Nahdatul Ulama) and the guidance of an order person of The Indonesian Council of Ulama in Indonesia.   The results of this study indicate that (a) The agreement of islamic organizations required to strengthen treatment and management of patiens with kidney failure in Indonesia. The scholars recommend transplantation as long as the benefits obtained are greater and do not endanger the person who receives (recipient) with the provisions of the organ in pairs (kidneys, eyes, feet, ears), not the only organs, such as the liver, brain, or heart. (b) The largest Islamic organizations in Indonesia such as MUI, NU and Muhammadiyah in general allowed this practice as long as they followed the provision of the shari'ah rules (Islam law). (c) Altruism has encouraged the behavior of Muslim kidney donors to help other humans, especially fellow Muslims. The other hand, they was not receive money for their action.   In the past, religion became a barrier of kidney transplant in Indonesia. However, now religion especially Islam has a significant role in transplantation. There have been many agreements and consensus of scholars (fatwa of ulama) from various conferences, institutions, islamic organizations that allow the practice of kidney transplant.